@inbook{ef34fdf6caaf4d04891fda89e270c9a2,
title = "Measurement of oncometabolites D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid",
abstract = "We describe a liquid chromatography-tandem mass spectrometry assay for measurement of d-2-hydroxyglutaric acid and l-2-hydroxyglutaric acid. These metabolites are increased in specific inborn errors of metabolism and are now recognized as oncometabolites. The measurement of d-2-hydroxyglutarate in peripheral blood may be used as a biomarker for screening and follow-up of patients with IDH-mutated acute myeloid leukemia.",
keywords = "2-Hydroxyglutaric acid, 2HG, Biomarker, D-2-Hydroxyglutaric acid, D-2HG, L-2-Hydroxyglutaric acid, L-2HG, LC-MS/MS, Liquid chromatography-tandem mass spectrometry, Oncometabolite",
author = "Jones, {Patricia M} and Richard Boriack and Struys, {Eduard A.} and Dinesh Rakheja",
year = "2017",
doi = "10.1007/978-1-4939-7142-8_14",
language = "English (US)",
volume = "1633",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "219--234",
booktitle = "Methods in Molecular Biology",
}