Maternal insulin resistance and preeclampsia

John C. Hauth; Rebecca G. Clifton; James M. Roberts; Leslie Myatt; Catherine Y. Spong; Kenneth J. Leveno; Michael W. Varner; Ronald J. Wapner; John M. Thorp; Brian M. Mercer; Alan M. Peaceman; Susan M. Ramin; Marshall W. Carpenter; Philip Samuels; Anthony Sciscione; Jorge E. Tolosa; George Saade; Yoram Sorokin; Garland D. Anderson

doi:10.1016/j.ajog.2011.02.024

Maternal insulin resistance and preeclampsia

John C. Hauth, Rebecca G. Clifton, James M. Roberts, Leslie Myatt, Catherine Y. Spong, Kenneth J. Leveno, Michael W. Varner, Ronald J. Wapner, John M. Thorp, Brian M. Mercer, Alan M. Peaceman, Susan M. Ramin, Marshall W. Carpenter, Philip Samuels, Anthony Sciscione, Jorge E. Tolosa, George Saade, Yoram Sorokin, Garland D. Anderson

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Objective: The purpose of this study was to determine whether mid-trimester insulin resistance is associated with subsequent preeclampsia. Study Design: This was a secondary analysis of 10,154 nulliparous women who received vitamin C and E or placebo daily from 9-16 weeks gestation until delivery. Of these, 1187 women had fasting plasma glucose and insulin tested between 22 and 26 weeks gestation. Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index. Results: Obese women were twice as likely to have a HOMA-IR result of <75th percentile. Hispanic and African American women had a higher percentage at <75th percentile for HOMA-IR than white women (42.2%, 27.2%, and 16.9%, respectively; P < .001). A HOMA-IR result of <75th percentile was higher among the 85 nulliparous women who subsequently had preeclampsia, compared with women who remained normotensive (40.5% vs 24.8%; adjusted odds ratio, 1.9; 95% confidence interval, 1.13.2). Quantitative insulin sensitivity check index results were similar to the HOMA-IR results. Conclusion: Midtrimester maternal insulin resistance is associated with subsequent preeclampsia.

Original language	English (US)
Pages (from-to)	327.e1-327.e6
Journal	American journal of obstetrics and gynecology
Volume	204
Issue number	4
DOIs	https://doi.org/10.1016/j.ajog.2011.02.024
State	Published - Apr 2011

Keywords

insulin resistance
low-risk nulliparous woman
preeclampsia

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2011.02.024

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Hauth, J. C., Clifton, R. G., Roberts, J. M., Myatt, L., Spong, C. Y., Leveno, K. J., Varner, M. W., Wapner, R. J., Thorp, J. M., Mercer, B. M., Peaceman, A. M., Ramin, S. M., Carpenter, M. W., Samuels, P., Sciscione, A., Tolosa, J. E., Saade, G., Sorokin, Y., & Anderson, G. D. (2011). Maternal insulin resistance and preeclampsia. American journal of obstetrics and gynecology, 204(4), 327.e1-327.e6. https://doi.org/10.1016/j.ajog.2011.02.024

Hauth, JC, Clifton, RG, Roberts, JM, Myatt, L, Spong, CY, Leveno, KJ, Varner, MW, Wapner, RJ, Thorp, JM, Mercer, BM, Peaceman, AM, Ramin, SM, Carpenter, MW, Samuels, P, Sciscione, A, Tolosa, JE, Saade, G, Sorokin, Y & Anderson, GD 2011, 'Maternal insulin resistance and preeclampsia', American journal of obstetrics and gynecology, vol. 204, no. 4, pp. 327.e1-327.e6. https://doi.org/10.1016/j.ajog.2011.02.024

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abstract = "Objective: The purpose of this study was to determine whether mid-trimester insulin resistance is associated with subsequent preeclampsia. Study Design: This was a secondary analysis of 10,154 nulliparous women who received vitamin C and E or placebo daily from 9-16 weeks gestation until delivery. Of these, 1187 women had fasting plasma glucose and insulin tested between 22 and 26 weeks gestation. Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index. Results: Obese women were twice as likely to have a HOMA-IR result of <75th percentile. Hispanic and African American women had a higher percentage at <75th percentile for HOMA-IR than white women (42.2%, 27.2%, and 16.9%, respectively; P < .001). A HOMA-IR result of <75th percentile was higher among the 85 nulliparous women who subsequently had preeclampsia, compared with women who remained normotensive (40.5% vs 24.8%; adjusted odds ratio, 1.9; 95% confidence interval, 1.13.2). Quantitative insulin sensitivity check index results were similar to the HOMA-IR results. Conclusion: Midtrimester maternal insulin resistance is associated with subsequent preeclampsia.",

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AU - Myatt, Leslie

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AU - Leveno, Kenneth J.

AU - Varner, Michael W.

AU - Wapner, Ronald J.

AU - Thorp, John M.

AU - Mercer, Brian M.

AU - Peaceman, Alan M.

AU - Ramin, Susan M.

AU - Carpenter, Marshall W.

AU - Samuels, Philip

AU - Sciscione, Anthony

AU - Tolosa, Jorge E.

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AB - Objective: The purpose of this study was to determine whether mid-trimester insulin resistance is associated with subsequent preeclampsia. Study Design: This was a secondary analysis of 10,154 nulliparous women who received vitamin C and E or placebo daily from 9-16 weeks gestation until delivery. Of these, 1187 women had fasting plasma glucose and insulin tested between 22 and 26 weeks gestation. Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index. Results: Obese women were twice as likely to have a HOMA-IR result of <75th percentile. Hispanic and African American women had a higher percentage at <75th percentile for HOMA-IR than white women (42.2%, 27.2%, and 16.9%, respectively; P < .001). A HOMA-IR result of <75th percentile was higher among the 85 nulliparous women who subsequently had preeclampsia, compared with women who remained normotensive (40.5% vs 24.8%; adjusted odds ratio, 1.9; 95% confidence interval, 1.13.2). Quantitative insulin sensitivity check index results were similar to the HOMA-IR results. Conclusion: Midtrimester maternal insulin resistance is associated with subsequent preeclampsia.

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Maternal insulin resistance and preeclampsia

Abstract

Keywords

ASJC Scopus subject areas

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