Maternal high-fat diet is associated with impaired fetal lung development

Reina S. Mayor; Katelyn E. Finch; Jordan Zehr; Eugenia Morselli; Michael D. Neinast; Aaron P. Frank; Lisa D. Hahner; Jason Wang; Dinesh Rakheja; Biff F Palmer; Charles R Rosenfeld; Rashmin C Savani; Deborah J. Clegg

doi:10.1152/ajplung.00105.2015

Maternal high-fat diet is associated with impaired fetal lung development

Reina S. Mayor, Katelyn E. Finch, Jordan Zehr, Eugenia Morselli, Michael D. Neinast, Aaron P. Frank, Lisa D. Hahner, Jason Wang, Dinesh Rakheja, Biff F Palmer, Charles R Rosenfeld, Rashmin C Savani, Deborah J. Clegg

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.

Original language	English (US)
Pages (from-to)	L360-L368
Journal	American Journal of Physiology - Lung Cellular and Molecular Physiology
Volume	309
Issue number	4
DOIs	https://doi.org/10.1152/ajplung.00105.2015
State	Published - Aug 18 2015

Keywords

Chorioamnionitis
Fetal growth restriction
Intrauterine growth restriction
Placental inflammation
Respiratory distress syndrome

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine
Physiology (medical)
Cell Biology

Access to Document

10.1152/ajplung.00105.2015

Cite this

Mayor, R. S., Finch, K. E., Zehr, J., Morselli, E., Neinast, M. D., Frank, A. P., Hahner, L. D., Wang, J., Rakheja, D., Palmer, B. F., Rosenfeld, C. R., Savani, R. C., & Clegg, D. J. (2015). Maternal high-fat diet is associated with impaired fetal lung development. American Journal of Physiology - Lung Cellular and Molecular Physiology, 309(4), L360-L368. https://doi.org/10.1152/ajplung.00105.2015

Mayor, RS, Finch, KE, Zehr, J, Morselli, E, Neinast, MD, Frank, AP, Hahner, LD, Wang, J, Rakheja, D , Palmer, BF , Rosenfeld, CR, Savani, RC & Clegg, DJ 2015, 'Maternal high-fat diet is associated with impaired fetal lung development', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 309, no. 4, pp. L360-L368. https://doi.org/10.1152/ajplung.00105.2015

@article{e1cf97e4ffed45da8c4a90bd31100a72,

title = "Maternal high-fat diet is associated with impaired fetal lung development",

abstract = "Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.",

keywords = "Chorioamnionitis, Fetal growth restriction, Intrauterine growth restriction, Placental inflammation, Respiratory distress syndrome",

author = "Mayor, {Reina S.} and Finch, {Katelyn E.} and Jordan Zehr and Eugenia Morselli and Neinast, {Michael D.} and Frank, {Aaron P.} and Hahner, {Lisa D.} and Jason Wang and Dinesh Rakheja and Palmer, {Biff F} and Rosenfeld, {Charles R} and Savani, {Rashmin C} and Clegg, {Deborah J.}",

note = "Publisher Copyright: {\textcopyright} 2015 the American Physiological Society.",

year = "2015",

month = aug,

day = "18",

doi = "10.1152/ajplung.00105.2015",

language = "English (US)",

volume = "309",

pages = "L360--L368",

journal = "American Journal of Physiology - Lung Cellular and Molecular Physiology",

issn = "1040-0605",

publisher = "American Physiological Society",

number = "4",

}

TY - JOUR

T1 - Maternal high-fat diet is associated with impaired fetal lung development

AU - Mayor, Reina S.

AU - Finch, Katelyn E.

AU - Zehr, Jordan

AU - Morselli, Eugenia

AU - Neinast, Michael D.

AU - Frank, Aaron P.

AU - Hahner, Lisa D.

AU - Wang, Jason

AU - Rakheja, Dinesh

AU - Palmer, Biff F

AU - Rosenfeld, Charles R

AU - Savani, Rashmin C

AU - Clegg, Deborah J.

PY - 2015/8/18

Y1 - 2015/8/18

N2 - Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.

AB - Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.

KW - Chorioamnionitis

KW - Fetal growth restriction

KW - Intrauterine growth restriction

KW - Placental inflammation

KW - Respiratory distress syndrome

UR - http://www.scopus.com/inward/record.url?scp=84939426903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939426903&partnerID=8YFLogxK

U2 - 10.1152/ajplung.00105.2015

DO - 10.1152/ajplung.00105.2015

M3 - Article

C2 - 26092997

AN - SCOPUS:84939426903

SN - 1040-0605

VL - 309

SP - L360-L368

JO - American Journal of Physiology - Lung Cellular and Molecular Physiology

JF - American Journal of Physiology - Lung Cellular and Molecular Physiology

IS - 4

ER -

Maternal high-fat diet is associated with impaired fetal lung development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this