Maternal folate deficiency and pregnancy wastage. I. Placental abruption

Peggy J. Whalley, Daniel E. Scott, Jack A. Pritchard

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


There is ample evidence that folate requirements are considerably increased during pregnancy and as the consequence some degree of folate deficiency is more apt to be found in pregnant than in nonpregnant women. When folate deficiency is of such intensity and duration as to cause maternal anemia, plasma folate levels are quite low, marrow cytomorphology is megaloblastic, and neutrophil nuclear hypersegmentation usually is apparent. These changes characteristic of maternal folate deficiency were neither more frequent nor more intense in women with placental abruption than in apparently healthy women during late pregnancy. Consequently these observations do not support the contention of some that placental abruption results from maternal folate deficiency.

Original languageEnglish (US)
Pages (from-to)670-678
Number of pages9
JournalAmerican journal of obstetrics and gynecology
Issue number5
StatePublished - Nov 1 1969

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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