TY - JOUR
T1 - Masters athletes exhibit larger regional brain volume and better cognitive performance than sedentary older adults
AU - Tseng, Benjamin Y.
AU - Uh, Jinsoo
AU - Rossetti, Heidi C.
AU - Cullum, C. Munro
AU - Diaz-Arrastia, Ramon F.
AU - Levine, Benjamin D.
AU - Lu, Hanzhang
AU - Zhang, Rong
PY - 2013/11
Y1 - 2013/11
N2 - Purpose To investigate differences in the age-related decline in brain tissue concentration between Masters athletes and sedentary older adults. Materials and Methods Twelve Masters athletes (MA) (three females, age = 72.4 ± 5.6 years, endurance training >15 years), 12 sedentary elderly (SE) similar in age and educational level (four females, age = 74.6 ± 4.3 years), and nine young controls (YC) (four females, age = 27.2 ± 3.6 years) participated. T1-weighted high-resolution (1 × 1 × 1mm 3) images were acquired. Voxel-based analysis was conducted to identify clusters showing tissue concentration differences with t-tests. Cognitive function was assessed using a standard clinical battery focused on executive function and memory. Results Two MA and two SE were unable to complete the magnetic resonance imaging (MRI) study. Both SE and MA showed lower gray matter (GM) concentrations than YC in the superior, inferior and middle frontal gyrus, superior temporal gyrus, postcentral gyrus, and the cingulate gyrus (PFDR-corrected < 0.001) and lower white matter (WM) concentrations in the inferior frontal gyrus and precentral gyrus (P FDR-corrected < 0.005). Notably, MA showed higher GM and WM concentrations than SE in the subgyral, cuneus, and precuneus regions related to visuospatial function, motor control, and working memory (P FDR-corrected < 0.005). After controlling for estimated intelligence, MA outperformed SE on tasks of letter (P < 0.01) and category (P < 0.05) fluency. Conclusion Life-long exercise may confer benefits to some aspects of executive function and age-related brain tissue loss in the regions related to visuospatial function, motor control, and working memory in older adults. J. Magn. Reson. Imaging 2013;38:1169-1176. © 2013 Wiley Periodicals, Inc.
AB - Purpose To investigate differences in the age-related decline in brain tissue concentration between Masters athletes and sedentary older adults. Materials and Methods Twelve Masters athletes (MA) (three females, age = 72.4 ± 5.6 years, endurance training >15 years), 12 sedentary elderly (SE) similar in age and educational level (four females, age = 74.6 ± 4.3 years), and nine young controls (YC) (four females, age = 27.2 ± 3.6 years) participated. T1-weighted high-resolution (1 × 1 × 1mm 3) images were acquired. Voxel-based analysis was conducted to identify clusters showing tissue concentration differences with t-tests. Cognitive function was assessed using a standard clinical battery focused on executive function and memory. Results Two MA and two SE were unable to complete the magnetic resonance imaging (MRI) study. Both SE and MA showed lower gray matter (GM) concentrations than YC in the superior, inferior and middle frontal gyrus, superior temporal gyrus, postcentral gyrus, and the cingulate gyrus (PFDR-corrected < 0.001) and lower white matter (WM) concentrations in the inferior frontal gyrus and precentral gyrus (P FDR-corrected < 0.005). Notably, MA showed higher GM and WM concentrations than SE in the subgyral, cuneus, and precuneus regions related to visuospatial function, motor control, and working memory (P FDR-corrected < 0.005). After controlling for estimated intelligence, MA outperformed SE on tasks of letter (P < 0.01) and category (P < 0.05) fluency. Conclusion Life-long exercise may confer benefits to some aspects of executive function and age-related brain tissue loss in the regions related to visuospatial function, motor control, and working memory in older adults. J. Magn. Reson. Imaging 2013;38:1169-1176. © 2013 Wiley Periodicals, Inc.
KW - MRI
KW - aging
KW - brain
KW - cognition
KW - exercise
UR - http://www.scopus.com/inward/record.url?scp=84880000842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880000842&partnerID=8YFLogxK
U2 - 10.1002/jmri.24085
DO - 10.1002/jmri.24085
M3 - Article
C2 - 23908143
AN - SCOPUS:84880000842
SN - 1053-1807
VL - 38
SP - 1169
EP - 1176
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 5
ER -