Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio

Salvatore Modica; Elena Bellafante; Antonio Moschetta

doi:10.2741/3563

Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio

Salvatore Modica, Elena Bellafante, Antonio Moschetta

Pharmacology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Recent discoveries highlighted intriguing molecular pathways that regulate synthesis, uptake, metabolism and excretion of bile acids and xenobiotics. The knowledge of factors that control these homeostatic processes is of clinical relevance to better understand the drug-drug interacting scenario as well as to control cholesterol detoxification, cholestasis and other conditions. Here we present evidences for the existence of a gut-liver safety network whereby activation of the nuclear receptor FXR, PXR, CAR trio provides protection against accumulation of exogenous and metabolic noxae.

Original language	English (US)
Pages (from-to)	4719-4745
Number of pages	27
Journal	Frontiers in Bioscience
Volume	14
Issue number	12
DOIs	https://doi.org/10.2741/3563
State	Published - Jan 1 2009

Keywords

Bile
Cholestasis
Cholesterol
Gene expression
Intestine
Lipids
Liver
Nuclear receptors
Review

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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KW - Cholestasis

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KW - Intestine

KW - Lipids

KW - Liver

KW - Nuclear receptors

KW - Review

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Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio

Abstract

Keywords

ASJC Scopus subject areas

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