@article{ef037387fcc94a04a279cae6abfda06b,
title = "Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue",
abstract = "The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using α-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.",
author = "Kazuhiko Yamada and Koji Yazawa and Akira Shimizu and Takehiro Iwanaga and Yosuke Hisashi and Matthew Nuhn and Patricia O'Malley and Shuji Nobori and Vagefi, {Parsia A.} and Clive Patience and Jay Fishman and Cooper, {David K.C.} and Hawley, {Robert J.} and Julia Greenstein and Schuurman, {Henk Jan} and Michel Awwad and Megan Sykes and Sachs, {David H.}",
note = "Funding Information: The authors wish to thank I. McMorrow for her review of the manuscript, S. Arn for herd management and quality control and M. Doherty, E. Samelson-Jones and B. Wong for help in manuscript preparation. D.H. Sachs, A. Shimizu, J. Fishman, D.K. Cooper and K. Yamada were consultants to Immerge Biotherapeutics, Inc. This work was supported in part by the US National Institutes of Health Program Project 1P01A45897 and by a Sponsored Research Agreement between the Massachusetts General hospital and Immerge Biotherapeutics, Inc.",
year = "2005",
month = jan,
doi = "10.1038/nm1172",
language = "English (US)",
volume = "11",
pages = "32--34",
journal = "Nature medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "1",
}