Mantle Cell Lymphoma With Mantle Zone Growth Pattern

Ji Yuan, Shaoying Li, Xin Liu, Ruijun Jeanna Su, Mingyi Chen, Xiaojun Wu, Gang Zheng, Lynette M. Smith, Lifu Wang, Yanxia Li, Cynthia Liu, Jiehao Zhou, Qi Shen, Linsheng Zhang, Endi Wang, Mina L. Xu, Zenggang Pan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


OBJECTIVES: To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS: The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS: The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy. CONCLUSIONS: MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.

Original languageEnglish (US)
Pages (from-to)132-145
Number of pages14
JournalAmerican journal of clinical pathology
Issue number2
StatePublished - Jul 5 2019


  • Cyclin D1
  • Mantle cell lymphoma
  • Mantle zone growth pattern
  • SOX11

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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