Mantle Cell Lymphoma With Mantle Zone Growth Pattern

Ji Yuan; Shaoying Li; Xin Liu; Ruijun Jeanna Su; Mingyi Chen; Xiaojun Wu; Gang Zheng; Lynette M. Smith; Lifu Wang; Yanxia Li; Cynthia Liu; Jiehao Zhou; Qi Shen; Linsheng Zhang; Endi Wang; Mina L. Xu; Zenggang Pan

doi:10.1093/ajcp/aqz043

Mantle Cell Lymphoma With Mantle Zone Growth Pattern

Ji Yuan, Shaoying Li, Xin Liu, Ruijun Jeanna Su, Mingyi Chen, Xiaojun Wu, Gang Zheng, Lynette M. Smith, Lifu Wang, Yanxia Li, Cynthia Liu, Jiehao Zhou, Qi Shen, Linsheng Zhang, Endi Wang, Mina L. Xu, Zenggang Pan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

OBJECTIVES: To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS: The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS: The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy. CONCLUSIONS: MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.

Original language	English (US)
Pages (from-to)	132-145
Number of pages	14
Journal	American journal of clinical pathology
Volume	152
Issue number	2
DOIs	https://doi.org/10.1093/ajcp/aqz043
State	Published - Jul 5 2019

Keywords

Cyclin D1
Mantle cell lymphoma
Mantle zone growth pattern
SOX11

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1093/ajcp/aqz043

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@article{cc941751694747f089db940ef159b701,

title = "Mantle Cell Lymphoma With Mantle Zone Growth Pattern",

abstract = "OBJECTIVES: To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS: The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS: The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy. CONCLUSIONS: MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.",

keywords = "Cyclin D1, Mantle cell lymphoma, Mantle zone growth pattern, SOX11",

author = "Ji Yuan and Shaoying Li and Xin Liu and Su, {Ruijun Jeanna} and Mingyi Chen and Xiaojun Wu and Gang Zheng and Smith, {Lynette M.} and Lifu Wang and Yanxia Li and Cynthia Liu and Jiehao Zhou and Qi Shen and Linsheng Zhang and Endi Wang and Xu, {Mina L.} and Zenggang Pan",

year = "2019",

month = jul,

day = "5",

doi = "10.1093/ajcp/aqz043",

language = "English (US)",

volume = "152",

pages = "132--145",

journal = "American journal of clinical pathology",

issn = "0002-9173",

publisher = "American Society of Clinical Pathologists",

number = "2",

}

TY - JOUR

T1 - Mantle Cell Lymphoma With Mantle Zone Growth Pattern

AU - Yuan, Ji

AU - Li, Shaoying

AU - Liu, Xin

AU - Su, Ruijun Jeanna

AU - Chen, Mingyi

AU - Wu, Xiaojun

AU - Zheng, Gang

AU - Smith, Lynette M.

AU - Wang, Lifu

AU - Li, Yanxia

AU - Liu, Cynthia

AU - Zhou, Jiehao

AU - Shen, Qi

AU - Zhang, Linsheng

AU - Wang, Endi

AU - Xu, Mina L.

AU - Pan, Zenggang

PY - 2019/7/5

Y1 - 2019/7/5

N2 - OBJECTIVES: To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS: The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS: The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy. CONCLUSIONS: MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.

AB - OBJECTIVES: To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS: The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS: The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy. CONCLUSIONS: MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.

KW - Cyclin D1

KW - Mantle cell lymphoma

KW - Mantle zone growth pattern

KW - SOX11

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U2 - 10.1093/ajcp/aqz043

DO - 10.1093/ajcp/aqz043

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C2 - 31140550

SN - 0002-9173

VL - 152

SP - 132

EP - 145

JO - American journal of clinical pathology

JF - American journal of clinical pathology

IS - 2

ER -

Mantle Cell Lymphoma With Mantle Zone Growth Pattern

Abstract

Keywords

ASJC Scopus subject areas

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