TY - JOUR
T1 - Manipulation of kinase signaling by bacterial pathogens
AU - Krachler, Anne Marie
AU - Woolery, Andrew R.
AU - Orth, Kim
PY - 2011/12
Y1 - 2011/12
N2 - Bacterial pathogens use effector proteins to manipulate their hosts to propagate infection. These effectors divert host cell signaling pathways to the benefit of the pathogen and frequently target kinase signaling cascades. Notable pathways that are usurped include the nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, and p21-activated kinase (PAK) pathways. Analyzing the functions of pathogenic effectors and their intersection with host kinase pathways has provided interesting insights into both the mechanisms of virulence and eukaryotic signaling.
AB - Bacterial pathogens use effector proteins to manipulate their hosts to propagate infection. These effectors divert host cell signaling pathways to the benefit of the pathogen and frequently target kinase signaling cascades. Notable pathways that are usurped include the nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, and p21-activated kinase (PAK) pathways. Analyzing the functions of pathogenic effectors and their intersection with host kinase pathways has provided interesting insights into both the mechanisms of virulence and eukaryotic signaling.
UR - http://www.scopus.com/inward/record.url?scp=84856785397&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856785397&partnerID=8YFLogxK
U2 - 10.1083/jcb.201107132
DO - 10.1083/jcb.201107132
M3 - Article
C2 - 22123833
AN - SCOPUS:84856785397
SN - 0021-9525
VL - 195
SP - 1083
EP - 1092
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 7
ER -