TY - JOUR
T1 - Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI
AU - Chirayil, Sara
AU - Jordan, Veronica Clavijo
AU - Martins, André F.
AU - Paranawithana, Namini
AU - Ratnakar, S. James
AU - Sherry, A. Dean
N1 - Funding Information:
The work was supported by grants from the NIH (DK095416 and EB-015908), the Cancer Prevention and Research Institute of Texas (RP180178), and the Robert A. Welch Foundation (AT-584).
Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/2/15
Y1 - 2021/2/15
N2 - A Mn(II)-based zinc-sensitive MRI contrast agent, MnPyC3A-BPEN, was prepared, characterized, and applied in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed that MnPyC3A-BPEN has superior kinetic inertness compared to GdDTPA, is less susceptible to transmetalation in the presence of excess Zn2+ ions, and less susceptible to transchelation by albumin. In comparison with other gadolinium-based zinc sensors bearing a single zinc binding moiety, MnPyC3A-BPEN appears to be a reliable alternative for imaging β-cell function in the pancreas and glucose-stimulated zinc secretion from the prostate.
AB - A Mn(II)-based zinc-sensitive MRI contrast agent, MnPyC3A-BPEN, was prepared, characterized, and applied in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed that MnPyC3A-BPEN has superior kinetic inertness compared to GdDTPA, is less susceptible to transmetalation in the presence of excess Zn2+ ions, and less susceptible to transchelation by albumin. In comparison with other gadolinium-based zinc sensors bearing a single zinc binding moiety, MnPyC3A-BPEN appears to be a reliable alternative for imaging β-cell function in the pancreas and glucose-stimulated zinc secretion from the prostate.
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U2 - 10.1021/acs.inorgchem.0c02688
DO - 10.1021/acs.inorgchem.0c02688
M3 - Article
C2 - 33507742
AN - SCOPUS:85100803892
SN - 0020-1669
VL - 60
SP - 2168
EP - 2177
JO - Inorganic Chemistry
JF - Inorganic Chemistry
IS - 4
ER -