Management of Nonfunctioning Recurrent Pituitary Adenomas

Christopher J. Farrell; Tomas Garzon-Muvdi; Judd H. Fastenberg; Gurston G. Nyquist; Mindy R. Rabinowitz; Marc R. Rosen; James J. Evans

doi:10.1016/j.nec.2019.05.006

Management of Nonfunctioning Recurrent Pituitary Adenomas

Christopher J. Farrell, Tomas Garzon-Muvdi, Judd H. Fastenberg, Gurston G. Nyquist, Mindy R. Rabinowitz, Marc R. Rosen, James J. Evans

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.

Original language	English (US)
Pages (from-to)	473-482
Number of pages	10
Journal	Neurosurgery clinics of North America
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.nec.2019.05.006
State	Published - Oct 2019

Keywords

KNOSP grade
Pituitary adenomas
Recurrent pituitary tumor
Transsphenoidal surgery

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/j.nec.2019.05.006

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@article{2d37312855ae4557890a403eaeca03e7,

title = "Management of Nonfunctioning Recurrent Pituitary Adenomas",

abstract = "Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.",

keywords = "KNOSP grade, Pituitary adenomas, Recurrent pituitary tumor, Transsphenoidal surgery",

author = "Farrell, {Christopher J.} and Tomas Garzon-Muvdi and Fastenberg, {Judd H.} and Nyquist, {Gurston G.} and Rabinowitz, {Mindy R.} and Rosen, {Marc R.} and Evans, {James J.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = oct,

doi = "10.1016/j.nec.2019.05.006",

language = "English (US)",

volume = "30",

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TY - JOUR

T1 - Management of Nonfunctioning Recurrent Pituitary Adenomas

AU - Farrell, Christopher J.

AU - Garzon-Muvdi, Tomas

AU - Fastenberg, Judd H.

AU - Nyquist, Gurston G.

AU - Rabinowitz, Mindy R.

AU - Rosen, Marc R.

AU - Evans, James J.

PY - 2019/10

Y1 - 2019/10

N2 - Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.

AB - Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.

KW - KNOSP grade

KW - Pituitary adenomas

KW - Recurrent pituitary tumor

KW - Transsphenoidal surgery

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DO - 10.1016/j.nec.2019.05.006

M3 - Review article

C2 - 31471054

AN - SCOPUS:85071350898

SN - 1042-3680

VL - 30

SP - 473

EP - 482

JO - Neurosurgery clinics of North America

JF - Neurosurgery clinics of North America

IS - 4

ER -

Management of Nonfunctioning Recurrent Pituitary Adenomas

Abstract

Keywords

ASJC Scopus subject areas

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