Management of Female Anterior Urethral Masses

Objectives Little is known about anterior female urethral masses and their management. Owing to their location, these masses are often missed on physical examination and are diagnosed at an advanced stage. Methods We report on 2 anterior urethral masses, with 1 mass arising from an anterior diverticulum. Results Both masses were difficult to identify on examination but were clearly delineated by magnetic resonance imaging. In both cases, a biopsy was essential for histologic characterization of the mass, predicting prognosis and dictating management options. One patient had high-grade clear-cell adenocarcinoma, necessitating an anterior exenteration. The other patient had a low-grade leiomyoma amenable to conservative management. Conclusions Tailored intervention for anterior female urethral masses can provide both symptomatic relief and mortality benefit.