Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-β precursor protein and Notch

Medicine & Life Sciences

• Presenilins 100%
• Amyloid Precursor Protein Secretases 86%
• Amyloid beta-Protein Precursor 80%
• Proteolysis 65%
• Membrane Proteins 28%
• Nickel 20%
• Protein Domains 17%
• Immunoprecipitation 16%
• Amyloid 16%
• Small Interfering RNA 14%
• Cell Line 10%
• Brain 8%

Chemical Compounds

• Protein Hydrolysis 75%
• Protein 28%
• Small Interfering RNA 16%
• Heterodimer 13%
• Peptide 6%
• Reduction 5%