TY - JOUR
T1 - Male breast cancer as a second primary cancer
T2 - Increased risk following lymphoma
AU - Farr, Deborah E.
AU - Thomas, Alexandra
AU - Khan, Seema Ahsan
AU - Schroeder, Mary C.
N1 - Publisher Copyright:
© AlphaMed Press 2017.
PY - 2017/8
Y1 - 2017/8
N2 - Background. Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with priorMBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported. Materials and Methods. Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973-2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) ofMBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival. Results. Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95% confidence interval [CI] 21.50-42.92, p< .001), lymphoma (SIR 1.58, 95% CI 1.08-2.22, p5.014), melanoma (SIR 1.26, 95% CI 0.80-1.89), urinary (SIR 1.05, 95% CI 0.74-1.43), colorectal (SIR 0.94, 95% CI 0.69-1.24), and prostate (SIR 0.93 95% CI 0.81-1.07). Apart from the known association with prior breast cancer, the only significant association was with lymphoma as an index cancer, although not significant with a Bonferroni correction. From 1975-2012, incidence of breast cancer as a first cancer increased at an annual percentage change of 1.3% while breast cancer as a SPC increased at 4.7% (both p values < .001). Conclusion.Male breast cancer as a SPC has increasedmarkedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics.
AB - Background. Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with priorMBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported. Materials and Methods. Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973-2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) ofMBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival. Results. Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95% confidence interval [CI] 21.50-42.92, p< .001), lymphoma (SIR 1.58, 95% CI 1.08-2.22, p5.014), melanoma (SIR 1.26, 95% CI 0.80-1.89), urinary (SIR 1.05, 95% CI 0.74-1.43), colorectal (SIR 0.94, 95% CI 0.69-1.24), and prostate (SIR 0.93 95% CI 0.81-1.07). Apart from the known association with prior breast cancer, the only significant association was with lymphoma as an index cancer, although not significant with a Bonferroni correction. From 1975-2012, incidence of breast cancer as a first cancer increased at an annual percentage change of 1.3% while breast cancer as a SPC increased at 4.7% (both p values < .001). Conclusion.Male breast cancer as a SPC has increasedmarkedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics.
KW - Incidence
KW - Male breast neoplasms
KW - Second primary neoplasm
KW - Surveillance, epidemiology, and end results program
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U2 - 10.1634/theoncologist.2016-0460
DO - 10.1634/theoncologist.2016-0460
M3 - Article
C2 - 28487463
AN - SCOPUS:85027346277
SN - 1083-7159
VL - 22
SP - 895
EP - 900
JO - Oncologist
JF - Oncologist
IS - 8
ER -