Making muscle or mitochondria by selective splicing of PGC-1α

Douglas P. Millay, Eric N. Olson

Research output: Contribution to journalShort surveypeer-review

16 Scopus citations


Endurance training induces the transcriptional coactivator PGC-1α in skeletal muscle, promoting mitochondrial biogenesis and skeletal muscle remodeling. In a recent issue of Cell, Ruas et al. (2012) show that resistance training regulates the splicing of a novel isoform of PGC-1α (PGC-1α4), which is sufficient to stimulate skeletal muscle hypertrophy.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalCell Metabolism
Issue number1
StatePublished - Jan 8 2013

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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