TY - JOUR
T1 - Making a neuron
T2 - Cdk5 in embryonic and adult neurogenesis
AU - Jessberger, Sebastian
AU - Gage, Fred H.
AU - Eisch, Amelia J.
AU - Lagace, Diane C.
N1 - Funding Information:
We would like to thank Mary Lynn Gage for editing the manuscript. Our research is supported by the NCCR Neural Plasticity and Repair, the Swiss National Science Foundation (3100A0-117744/1), an ETH grant (ETH-0108-1), the Théodore Ott and Novartis Foundation (to S.J.), NIH grants R21 DA023701 and K02 DA023555 (to A.J.E.) and salary support from the Heart and Stroke Foundation Centre for Stroke Recovery (D.C.L.). The authors declare they have no conflict of interest.
PY - 2009/11
Y1 - 2009/11
N2 - Cyclin-dependent kinase 5 (Cdk5) has been implicated in the migration, maturation and survival of neurons born during embryonic development. New evidence suggests that Cdk5 has comparable but also distinct functions in adult neurogenesis. Here we summarize accumulating evidence on the role of Cdk5 in regulation of the cell cycle, migration, survival, maturation and neuronal integration. We specifically highlight the many similarities and few tantalizing differences in the roles of Cdk5 in the embryonic and adult brain. We discuss the signaling pathways that might contribute to Cdk5 action in regulating embryonic and adult neurogenesis, highlighting future research directions that will help to clarify the mechanisms underlying lifelong neurogenesis in the mammalian brain.
AB - Cyclin-dependent kinase 5 (Cdk5) has been implicated in the migration, maturation and survival of neurons born during embryonic development. New evidence suggests that Cdk5 has comparable but also distinct functions in adult neurogenesis. Here we summarize accumulating evidence on the role of Cdk5 in regulation of the cell cycle, migration, survival, maturation and neuronal integration. We specifically highlight the many similarities and few tantalizing differences in the roles of Cdk5 in the embryonic and adult brain. We discuss the signaling pathways that might contribute to Cdk5 action in regulating embryonic and adult neurogenesis, highlighting future research directions that will help to clarify the mechanisms underlying lifelong neurogenesis in the mammalian brain.
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U2 - 10.1016/j.tins.2009.07.002
DO - 10.1016/j.tins.2009.07.002
M3 - Review article
C2 - 19782409
AN - SCOPUS:70350120731
SN - 0378-5912
VL - 32
SP - 575
EP - 582
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 11
ER -