Major depression and the risk of attempted suicide

Kevin M. Malone, Gretchen L. Haas, John A. Sweeney, J. John Mann

Research output: Contribution to journalArticlepeer-review

263 Scopus citations


We examined the risk of attempted suicide in 100 inpatients during a major depressive episode. We hypothesized that patients who attempt suicide have a vulnerability for suicidal behavior independent of severity or duration of depression, manifested by suicide attempts early in the course of a depressive episode. The first 3 months after the onset of an MDE and the first 5 years after the lifetime onset of major depressive disorder represented the highest-risk period for attempted suicide, independent of the severity or duration of depression. Familial, genetic, early-life loss experiences and comorbid alcoholism may be causal factors.

Original languageEnglish (US)
Pages (from-to)173-185
Number of pages13
JournalJournal of affective disorders
Issue number3
StatePublished - Jun 8 1995

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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