@article{90ac24ad17f243a3908909b96db72a9c,
title = "Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory",
abstract = "Inhibitory neurotransmission in amygdala is important for fear learning and memory. However, mechanisms that control the inhibitory activity in amygdala are not well understood. We provide evidence that neuregulin 1 (NRG1) and its receptor ErbB4 tyrosine kinase are critical for maintaining GABAergic activity in amygdala. Neutralizing endogenous NRG1, inhibition, or genetic ablation of ErbB4, which was expressed in a majority of palvalbumin (PV)+ neurons in amygdala, reduced GABAergic transmission and inhibited tone-cued fear conditioning. Specific ablation of ErbB4 in PV+ neurons reduced eIPSC/eEPSC ratios and impaired fear conditioning. Notably, expression of ErbB4 in amygdala was sufficient to diminish synaptic dysfunction and fear conditioning deficits in PV-ErbB4-/- mice. These observations indicated that NRG1 signaling maintains high GABAergic activity in amygdala and, thus, regulates fear memory. Considering that both NRG1 and ErbB4 are susceptibility genes of schizophrenia, our study sheds light on potential pathophysiological mechanisms of this disorder.",
author = "Yisheng Lu and Sun, {Xiang Dong} and Hou, {Feng Qing} and Bi, {Lin Lin} and Yin, {Dong Min} and Fang Liu and Chen, {Yong Jun} and Bean, {Jonathan C.} and Jiao, {Hui Feng} and Xihui Liu and Li, {Bao Ming} and Xiong, {Wen Cheng} and Gao, {Tian Ming} and Lin Mei",
note = "Funding Information: This work is supported in part by grants from the NIH (L.M. and W.-C.X.), National Alliance for Research on Schizophrenia and Depression (NARSAD) (L.M., Y.L., and D.-M.Y.), National Natural Science Foundation of China (81329003, U1201225, 31430032, 31271171, and 81471116 to T.-M.G., B.-M.L., and L.M.), Guangzhou Science and Technology Project (7411802013939 to T.-M.G.), and Program for Changjiang Scholars and Innovative Research Team in University (IRT1142 to T.-M G.). L.M. is a NARSAD Distinguished Investigator. Y.L. and D.-M.Y. were NARSAD Young Investigators. We thank Dr. Hongjun Song for lentivirus vectors; Dr. Kathleen Yee and Dr. Martin Gassmann for ErbB4 null mutant mice; Dr. Alvin Terry and Dr. Patrick Callahan of the Small Animal Behavioral Core at Georgia Regents University for assistance in behavioral analysis; and Dr. Alexis Stranahan for advice and assistance in stereology analysis. Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",
year = "2014",
month = nov,
day = "19",
doi = "10.1016/j.neuron.2014.09.029",
language = "English (US)",
volume = "84",
pages = "835--846",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}