Magnitude and Time-Trend Analysis of Postendoscopy Esophageal Adenocarcinoma: A Systematic Review and Meta-analysis

Post-Endoscopy Esophageal Adenocarcinoma Consensus Panel

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Background & Aims: Identification of postendoscopy esophageal adenocarcinoma (PEEC) among Barrett's esophagus (BE) patients presents an opportunity to improve survival of esophageal adenocarcinoma (EAC). We aimed to estimate the proportion of PEEC within the first year after BE diagnosis. Methods: Multiple databases (Medline, Embase, Scopus, and Cochrane databases) were searched until September 2020 for original studies with at least 1-year follow-up evaluation that reported EAC and/or high-grade dysplasia (HGD) in the first year after index endoscopy in nondysplastic BE, low-grade dysplasia, or indefinite dysplasia. The proportions of PEEC defined using EAC alone and EAC+HGD were calculated by dividing EAC or EAC+HGD in the first year over the total number of EAC or EAC+HGD, respectively. Results: We included 52 studies with 145,726 patients and a median follow-up period of 4.8 years. The proportion of PEEC (EAC) was 21% (95% CI, 13–31) and PEEC (EAC+HGD) was 26% (95% CI, 19–34). Among studies with nondysplastic BE only, the PEEC (EAC) proportion was 17% (95% CI, 11–23) and PEEC (EAC+HGD) was 14% (95% CI, 8–19). Among studies with 5 or more years of follow-up evaluation, the PEEC (EAC) proportion was 10% and PEEC (EAC+HGD) was 19%. Meta-regression analysis showed a strong inverse relationship between PEEC and incident EAC (P < .001). The PEEC (EAC) proportion increased from 5% in studies published before 2000 to 30% after 2015. Substantial heterogeneity was observed for most analyses. Conclusions: PEEC accounts for a high proportion of HGD/EACs and is proportional to reduction in incident EAC. Using best endoscopic techniques now and performing future research on improving neoplasia detection through implementation of quality measures and educational tools is needed to reduce PEEC.

Original languageEnglish (US)
Pages (from-to)e31-e50
JournalClinical Gastroenterology and Hepatology
Issue number2
StatePublished - Feb 2022


  • Endoscopy
  • Missed Esophageal Adenocarcinoma
  • Quality
  • Surveillance

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Magnitude and Time-Trend Analysis of Postendoscopy Esophageal Adenocarcinoma: A Systematic Review and Meta-analysis'. Together they form a unique fingerprint.

Cite this