Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

Hua Ai; Christopher Flask; Brent Weinberg; Xintao Shuai; Many D. Pagel; David Farrell; Jeffrey Duerk; Jinming Gao

doi:10.1002/adma.200401904

Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

Hua Ai, Christopher Flask, Brent Weinberg, Xintao Shuai, Many D. Pagel, David Farrell, Jeffrey Duerk, Jinming Gao

Research output: Contribution to journal › Article › peer-review

434 Scopus citations

Abstract

The development of super-paramagnetic polymer micelles as a new class of magnetic resonance imaging (MRI) probes with high spin-spin relaxivity and sensitivity, was reported. The micelles consists of a cluster of hydrophobic magnetite particles encapsulated inside the hydrophobic core of polymeric micelle whose surface is stabilized by a poly(ethylene glycol) (PEG) shell. The unique core-shell composite design helps to achieve an ultrasensitive MRI detection limit of 5.2 μgmL^-1, and promises for an application in molecular imaging and image-visible drug delivery applications. An amphiphilic diblock copolymer of poly(η-caprolactone)-b-polyethylene glycol was used in the study.

Original language	English (US)
Pages (from-to)	1949-1952
Number of pages	4
Journal	Advanced Materials
Volume	17
Issue number	16
DOIs	https://doi.org/10.1002/adma.200401904
State	Published - Aug 18 2005

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.200401904

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AU - Ai, Hua

AU - Flask, Christopher

AU - Weinberg, Brent

AU - Shuai, Xintao

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AU - Farrell, David

AU - Duerk, Jeffrey

AU - Gao, Jinming

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AB - The development of super-paramagnetic polymer micelles as a new class of magnetic resonance imaging (MRI) probes with high spin-spin relaxivity and sensitivity, was reported. The micelles consists of a cluster of hydrophobic magnetite particles encapsulated inside the hydrophobic core of polymeric micelle whose surface is stabilized by a poly(ethylene glycol) (PEG) shell. The unique core-shell composite design helps to achieve an ultrasensitive MRI detection limit of 5.2 μgmL-1, and promises for an application in molecular imaging and image-visible drug delivery applications. An amphiphilic diblock copolymer of poly(η-caprolactone)-b-polyethylene glycol was used in the study.

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Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

Abstract

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