TY - JOUR
T1 - Magnetic resonance/transrectal ultrasound fusion biopsy of the prostate compared to systematic 12-core biopsy for the diagnosis and characterization of prostate cancer
T2 - Multi-institutional retrospective analysis of 389 patients
AU - Mariotti, Guilherme C.
AU - Costa, Daniel N
AU - Pedrosa, Ivan
AU - Falsarella, Priscila M.
AU - Martins, Tatiana
AU - Roehrborn, Claus
AU - Rofsky, Neil M
AU - Xi, Yin
AU - Thais, Thais C.
AU - Queiroz, Marcos R.
AU - Lotan, Yair
AU - Garcia, Rodrigo G.
AU - Lemos, Gustavo C.
AU - Baroni, Ronaldo H.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - Objective: To determine the incremental diagnostic value of targeted biopsies added to an extended sextant biopsy scheme on a per-patient, risk-stratified basis in 2 academic centers using different multiparametric magnetic resonance imaging (MRI) protocols, a large group of radiologists, multiple biopsy systems, and different biopsy operators. Materials and Methods: All patients with suspected prostate cancer (PCa) who underwent multiparametric MRI of the prostate in 2 academic centers between February 2013 and January 2015 followed by systematic and targeted MRI-transrectal ultrasound fusion biopsy were reviewed. Risk-stratified detection rate using systematic biopsies was compared with targeted biopsies on a per-patient basis. The McNemar test was used to compare diagnostic performance of the 2 approaches. Results: A total of 389 men met eligibility criteria. PCa was diagnosed in 47% (182/389), 52%(202/389), and 60%(235/389) of patients using the targeted, systematic, and combined (targeted plus systematic) approach, respectively. Compared with systematic biopsy, targeted biopsy diagnosed 11% (37 vs. 26) more intermediate-to-high risk (P
AB - Objective: To determine the incremental diagnostic value of targeted biopsies added to an extended sextant biopsy scheme on a per-patient, risk-stratified basis in 2 academic centers using different multiparametric magnetic resonance imaging (MRI) protocols, a large group of radiologists, multiple biopsy systems, and different biopsy operators. Materials and Methods: All patients with suspected prostate cancer (PCa) who underwent multiparametric MRI of the prostate in 2 academic centers between February 2013 and January 2015 followed by systematic and targeted MRI-transrectal ultrasound fusion biopsy were reviewed. Risk-stratified detection rate using systematic biopsies was compared with targeted biopsies on a per-patient basis. The McNemar test was used to compare diagnostic performance of the 2 approaches. Results: A total of 389 men met eligibility criteria. PCa was diagnosed in 47% (182/389), 52%(202/389), and 60%(235/389) of patients using the targeted, systematic, and combined (targeted plus systematic) approach, respectively. Compared with systematic biopsy, targeted biopsy diagnosed 11% (37 vs. 26) more intermediate-to-high risk (P
KW - Biopsy
KW - Early detection of cancer
KW - Magnetic Resonance Imaging
KW - Prostatic Neoplasms
KW - Risk assessment
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U2 - 10.1016/j.urolonc.2016.04.008
DO - 10.1016/j.urolonc.2016.04.008
M3 - Article
C2 - 27197921
AN - SCOPUS:84966839125
SN - 1078-1439
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
ER -