Lymphotoxin signalling in immune homeostasis and the control of microorganisms

Vaibhav Upadhyay, Yang Xin Fu

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Lymphotoxin (LT) is a member of the tumour necrosis factor (TNF) superfamily that was originally thought to be functionally redundant to TNF, but these proteins were later found to have independent roles in driving lymphoid organogenesis. More recently, LT-mediated signalling has been shown to actively contribute to effector immune responses. LT regulates dendritic cell and CD4+ T cell homeostasis in the steady state and determines the functions of these cells during pathogenic challenges. The LT receptor pathway is essential for controlling pathogens and even contributes to the regulation of the intestinal microbiota, with recent data suggesting that LT-induced changes in the microbiota promote metabolic disease. In this Review, we discuss these newly defined roles for LT, with a particular focus on how the LT receptor pathway regulates innate and adaptive immune responses to microorganisms.

Original languageEnglish (US)
Pages (from-to)270-279
Number of pages10
JournalNature Reviews Immunology
Issue number4
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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