Abstract
We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the presence of LXRα, a member of the nuclear receptor superfamily. LXRα shows a specific pattern of expression in visceral organs, thereby restricting the response to certain tissues. Retinoid trans-activation occurs selectively on a distinct response element termed an LXRE. Significantly, neither RXR homodimers nor RXR/RAR heterodimers are able to substitute for LXRα in mediating this retinoid response. We provide evidence that the retinoid response on the LXRE is the result of a unique interaction between LXRα and endogenous RXR, which, unlike in the RXR/RAR heterodimer, makes RXR competent to respond to retinoids. Thus, the interaction with LXRα shifts RXR from its role described previously as a silent, DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXREs.
Original language | English (US) |
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Pages (from-to) | 1033-1045 |
Number of pages | 13 |
Journal | Genes and Development |
Volume | 9 |
Issue number | 9 |
DOIs | |
State | Published - May 1 1995 |
Keywords
- 9-cis retinoic acid
- LXR
- RXR
- methoprene acid
- orphan receptor
- retinoid receptors
ASJC Scopus subject areas
- Genetics
- Developmental Biology