Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

Ayumu Taguchi; Katerina Politi; Sharon J. Pitteri; William W. Lockwood; Vitor M. Faça; Karen Kelly-Spratt; Chee Hong Wong; Qing Zhang; Alice Chin; Kwon Sik Park; Gary Goodman; Adi F. Gazdar; Julien Sage; Daniela M. Dinulescu; Raju Kucherlapati; Ronald A. DePinho; Christopher J. Kemp; Harold E. Varmus; Samir M. Hanash

doi:10.1016/j.ccr.2011.08.007

Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

Ayumu Taguchi, Katerina Politi, Sharon J. Pitteri, William W. Lockwood, Vitor M. Faça, Karen Kelly-Spratt, Chee Hong Wong, Qing Zhang, Alice Chin, Kwon Sik Park, Gary Goodman, Adi F. Gazdar, Julien Sage, Daniela M. Dinulescu, Raju Kucherlapati, Ronald A. DePinho, Christopher J. Kemp, Harold E. Varmus, Samir M. Hanash

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Abstract

We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.

Original language	English (US)
Pages (from-to)	289-299
Number of pages	11
Journal	Cancer Cell
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.ccr.2011.08.007
State	Published - Sep 2011

ASJC Scopus subject areas

Oncology
Cancer Research

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Taguchi, A., Politi, K., Pitteri, S. J., Lockwood, W. W., Faça, V. M., Kelly-Spratt, K., Wong, C. H., Zhang, Q., Chin, A., Park, K. S., Goodman, G., Gazdar, A. F., Sage, J., Dinulescu, D. M., Kucherlapati, R., DePinho, R. A., Kemp, C. J., Varmus, H. E., & Hanash, S. M. (2011). Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell, 20(3), 289-299. https://doi.org/10.1016/j.ccr.2011.08.007

Taguchi, A, Politi, K, Pitteri, SJ, Lockwood, WW, Faça, VM, Kelly-Spratt, K, Wong, CH, Zhang, Q, Chin, A, Park, KS, Goodman, G, Gazdar, AF, Sage, J, Dinulescu, DM, Kucherlapati, R, DePinho, RA, Kemp, CJ, Varmus, HE & Hanash, SM 2011, 'Lung cancer signatures in plasma based on proteome profiling of mouse tumor models', Cancer Cell, vol. 20, no. 3, pp. 289-299. https://doi.org/10.1016/j.ccr.2011.08.007

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title = "Lung cancer signatures in plasma based on proteome profiling of mouse tumor models",

abstract = "We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.",

author = "Ayumu Taguchi and Katerina Politi and Pitteri, {Sharon J.} and Lockwood, {William W.} and Fa{\c c}a, {Vitor M.} and Karen Kelly-Spratt and Wong, {Chee Hong} and Qing Zhang and Alice Chin and Park, {Kwon Sik} and Gary Goodman and Gazdar, {Adi F.} and Julien Sage and Dinulescu, {Daniela M.} and Raju Kucherlapati and DePinho, {Ronald A.} and Kemp, {Christopher J.} and Varmus, {Harold E.} and Hanash, {Samir M.}",

note = "Funding Information: Funding support was provided by the National Cancer Institute's Mouse Models of Human Cancer program; the Canary, Labrecque, and Uniting Against Lung Cancer Foundations; and the Department of Defense (DOD) Congressionally Mandated Lung Cancer Research program. K.S.P. is a Parker B. Francis Fellow. D.M.D. is supported by the DOD (grant no. W81XWH-10-1-0263) and by the Burroughs Wellcome, V Foundation, Mary Kay Ash, and Rivkin Foundations. The authors declare no competing financial interests. ",

year = "2011",

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doi = "10.1016/j.ccr.2011.08.007",

language = "English (US)",

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pages = "289--299",

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AU - Politi, Katerina

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AU - Kelly-Spratt, Karen

AU - Wong, Chee Hong

AU - Zhang, Qing

AU - Chin, Alice

AU - Park, Kwon Sik

AU - Goodman, Gary

AU - Gazdar, Adi F.

AU - Sage, Julien

AU - Dinulescu, Daniela M.

AU - Kucherlapati, Raju

AU - DePinho, Ronald A.

AU - Kemp, Christopher J.

AU - Varmus, Harold E.

AU - Hanash, Samir M.

N1 - Funding Information: Funding support was provided by the National Cancer Institute's Mouse Models of Human Cancer program; the Canary, Labrecque, and Uniting Against Lung Cancer Foundations; and the Department of Defense (DOD) Congressionally Mandated Lung Cancer Research program. K.S.P. is a Parker B. Francis Fellow. D.M.D. is supported by the DOD (grant no. W81XWH-10-1-0263) and by the Burroughs Wellcome, V Foundation, Mary Kay Ash, and Rivkin Foundations. The authors declare no competing financial interests.

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AB - We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.

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Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

Abstract

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