Lung cancer in never smokers - A different disease

Sophie Sun, Joan H. Schiller, Adi F. Gazdar

Research output: Contribution to journalReview articlepeer-review

1139 Scopus citations


Although most lung cancers are a result of smoking, approximately 25% of lung cancer cases worldwide are not attributable to tobacco use, accounting for over 300,000 deaths each year. Striking differences in the epidemiological, clinical and molecular characteristics of lung cancers arising in never smokers versus smokers have been identified, suggesting that they are separate entities. This Review summarizes our current knowledge of this unique and poorly understood disease.

Original languageEnglish (US)
Pages (from-to)778-790
Number of pages13
JournalNature Reviews Cancer
Issue number10
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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