LRP: A bright beacon at the blood-brain barrier

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


Ever more unexpected roles for the LDL receptor gene family in a variety of cellular signaling pathways continue to emerge. Three recent studies now add another function to this collection (see the related article beginning on page 1533). By interacting with active tissue-type plasminogen activator, LDL receptor-related protein appears to control permeability of the blood-brain barrier, vascular tone, and the expression of MMPs. All of these parameters impact upon postischemic infarct size following stroke. These novel findings are discussed in the context of known mechanisms of signaling by the LDL receptor family.

Original languageEnglish (US)
Pages (from-to)1483-1485
Number of pages3
JournalJournal of Clinical Investigation
Issue number10
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Medicine(all)


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