TY - JOUR
T1 - Low molecular weight dextran provides similar optical coherence tomography coronary imaging compared to radiographic contrast media
AU - Frick, Kyle
AU - Michael, Tesfaldet T.
AU - Alomar, Mohammed
AU - Mohammed, Atif
AU - Rangan, Bavana V.
AU - Abdullah, Shuaib
AU - Grodin, Jerrold
AU - Hastings, Jeffrey L.
AU - Banerjee, Subhash
AU - Brilakis, Emmanouil S.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background: Optical coherence tomography (OCT) coronary imaging requires displacement of red blood cells from the vessel lumen. This is usually accomplished using radiographic contrast. Low molecular weight dextran has low cost and is safe in low volumes. In the present study, we compared dextran with contrast for coronary OCT imaging.Methods: Fifty-one vessels in 26 patients were sequentially imaged using manual injection of radiographic contrast (iodixanol) and dextran. OCT images were analyzed at 1 mm intervals to determine the image clarity (defined as a visible lumen border>270°) and to measure the lumen area and lumen diameter. To correct for the refractive index of dextran, the dextran area measurements were multiplied by 1.117 and the dextran length measurements were multiplied by 1.057.Results: A total of 3,418 cross-sections (1,709 with contrast and 1,709 with dextran) were analyzed. There were no complications related to OCT imaging or to contrast or dextran administration. Clear image segments were observed in 97.0% vs. 96.7% of the cross-sections obtained with contrast and dextran, respectively (P ± 0.45). The mean lumen areas were also similar:6.69 6 1.95 mm2 with iodixanol vs. 7.06 6 2.06 mm2 with dextran (correlation coefficient 0.984).Conclusions: The image quality and measurements during OCT image acquisition are similar for dextran and contrast. Dextran could be used instead of contrast for OCT imaging, especially in patients in whom contrast load minimization is desired.
AB - Background: Optical coherence tomography (OCT) coronary imaging requires displacement of red blood cells from the vessel lumen. This is usually accomplished using radiographic contrast. Low molecular weight dextran has low cost and is safe in low volumes. In the present study, we compared dextran with contrast for coronary OCT imaging.Methods: Fifty-one vessels in 26 patients were sequentially imaged using manual injection of radiographic contrast (iodixanol) and dextran. OCT images were analyzed at 1 mm intervals to determine the image clarity (defined as a visible lumen border>270°) and to measure the lumen area and lumen diameter. To correct for the refractive index of dextran, the dextran area measurements were multiplied by 1.117 and the dextran length measurements were multiplied by 1.057.Results: A total of 3,418 cross-sections (1,709 with contrast and 1,709 with dextran) were analyzed. There were no complications related to OCT imaging or to contrast or dextran administration. Clear image segments were observed in 97.0% vs. 96.7% of the cross-sections obtained with contrast and dextran, respectively (P ± 0.45). The mean lumen areas were also similar:6.69 6 1.95 mm2 with iodixanol vs. 7.06 6 2.06 mm2 with dextran (correlation coefficient 0.984).Conclusions: The image quality and measurements during OCT image acquisition are similar for dextran and contrast. Dextran could be used instead of contrast for OCT imaging, especially in patients in whom contrast load minimization is desired.
KW - Coronary artery disease
KW - Dextran
KW - Imaging
KW - Radiographic contrast
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U2 - 10.1002/ccd.25092
DO - 10.1002/ccd.25092
M3 - Article
C2 - 23804461
AN - SCOPUS:84912139705
SN - 1522-1946
VL - 84
SP - 727
EP - 731
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
IS - 5
ER -