Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Virginie Mansuy-Aubert; Laurent Gautron; Syann Lee; Angie L. Bookout; Christine M. Kusminski; Kai Sun; Yuan Zhang; Philipp E. Scherer; David J. Mangelsdorf; Joel K. Elmquist

doi:10.7554/eLife.06667

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Virginie Mansuy-Aubert, Laurent Gautron, Syann Lee, Angie L. Bookout, Christine M. Kusminski, Kai Sun, Yuan Zhang, Philipp E. Scherer, David J. Mangelsdorf, Joel K. Elmquist

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.

Original language	English (US)
Article number	e06667
Journal	eLife
Volume	4
Issue number	JUNE
DOIs	https://doi.org/10.7554/eLife.06667
State	Published - Jun 15 2015

ASJC Scopus subject areas

Neuroscience(all)
Immunology and Microbiology(all)
Biochemistry, Genetics and Molecular Biology(all)

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title = "Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure",

abstract = "Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.",

author = "Virginie Mansuy-Aubert and Laurent Gautron and Syann Lee and Bookout, {Angie L.} and Kusminski, {Christine M.} and Kai Sun and Yuan Zhang and Scherer, {Philipp E.} and Mangelsdorf, {David J.} and Elmquist, {Joel K.}",

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AU - Mansuy-Aubert, Virginie

AU - Gautron, Laurent

AU - Lee, Syann

AU - Bookout, Angie L.

AU - Kusminski, Christine M.

AU - Sun, Kai

AU - Zhang, Yuan

AU - Scherer, Philipp E.

AU - Mangelsdorf, David J.

AU - Elmquist, Joel K.

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Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Abstract

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