TY - JOUR
T1 - Longitudinal changes of structural connectivity in traumatic axonal injury
AU - Wang, J. Y.
AU - Bakhadirov, K.
AU - Abdi, H.
AU - Devous, M. D.
AU - Marquez De La Plata, C. D.
AU - Moore, C.
AU - Madden, C. J.
AU - Diaz-Arrastia, R.
N1 - Funding Information:
Dr. Wang, Dr. Bakhadirov, and Dr. Abdi report no disclosures. Dr. Devous serves on a scientific advisory board and as a consultant for Avid Radiopharmaceuticals, Inc.; served as an Associate Editor for the Journal of Experimental Biology ; receives research support from Avid Radiopharmaceuticals, Inc., the NIH (NIA, NIDRR/US Dept. Ed.), and the Alzheimer's Association; and holds stock/stock options in Avid Radiopharmaceuticals, Inc. Dr. Marquez de la Plata, C. Moore, and Dr. Madden report no disclosures. Dr. Diaz-Arrastia serves on the speakers' bureau for and has received funding for travel and speaker honoraria from UCB; serves on the editorial board of the Journal of Neurotrauma ; and receives research support from the NIH/NIDRR and the Alzheimer's Association.
PY - 2011/8/30
Y1 - 2011/8/30
N2 - Objectives: To identify structural connectivity change occurring during the first 6 months after traumatic brain injury and to evaluate the utility of diffusion tensor tractography for predicting long-term outcome. Methods: The participants were 28 patients with mild to severe traumatic axonal injury and 20 age- and sex-matched healthy control subjects. Neuroimaging was obtained 0-9 days postinjury for acute scans and 6-14 months postinjury for chronic scans. Long-term outcome was evaluated on the day of the chronic scan. Twenty-eight fiber regions of 9 major white matter structures were reconstructed, and reliable tractography measurements were determined and used. Results: Although most (23 of 28) patients had severe brain injury, their long-term outcome ranged from good recovery (16 patients) to moderately (5 patients) and severely disabled (7 patients). In concordance with the diverse outcome, the white matter change in patients was heterogeneous, ranging from improved structural connectivity, through no change, to deteriorated connectivity. At the group level, all 9 fiber tracts deteriorated significantly with 7 (corpus callosum, cingulum, angular bundle, cerebral peduncular fibers, uncinate fasciculus, and inferior longitudinal and fronto-occipital fasciculi) showing structural damage acutely and 2 (fornix body and left arcuate fasciculus) chronically. Importantly, the amount of change in tractography measurements correlated with patients' long-term outcome. Acute tractography measurements were able to predict patients' learning and memory performance; chronic measurements also determined performance on processing speed and executive function. Conclusions: Diffusion tensor tractography is a valuable tool for identifying structural connectivity changes occurring between the acute and chronic stages of traumatic brain injury and for predicting patients' long-term outcome.
AB - Objectives: To identify structural connectivity change occurring during the first 6 months after traumatic brain injury and to evaluate the utility of diffusion tensor tractography for predicting long-term outcome. Methods: The participants were 28 patients with mild to severe traumatic axonal injury and 20 age- and sex-matched healthy control subjects. Neuroimaging was obtained 0-9 days postinjury for acute scans and 6-14 months postinjury for chronic scans. Long-term outcome was evaluated on the day of the chronic scan. Twenty-eight fiber regions of 9 major white matter structures were reconstructed, and reliable tractography measurements were determined and used. Results: Although most (23 of 28) patients had severe brain injury, their long-term outcome ranged from good recovery (16 patients) to moderately (5 patients) and severely disabled (7 patients). In concordance with the diverse outcome, the white matter change in patients was heterogeneous, ranging from improved structural connectivity, through no change, to deteriorated connectivity. At the group level, all 9 fiber tracts deteriorated significantly with 7 (corpus callosum, cingulum, angular bundle, cerebral peduncular fibers, uncinate fasciculus, and inferior longitudinal and fronto-occipital fasciculi) showing structural damage acutely and 2 (fornix body and left arcuate fasciculus) chronically. Importantly, the amount of change in tractography measurements correlated with patients' long-term outcome. Acute tractography measurements were able to predict patients' learning and memory performance; chronic measurements also determined performance on processing speed and executive function. Conclusions: Diffusion tensor tractography is a valuable tool for identifying structural connectivity changes occurring between the acute and chronic stages of traumatic brain injury and for predicting patients' long-term outcome.
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U2 - 10.1212/WNL.0b013e31822c61d7
DO - 10.1212/WNL.0b013e31822c61d7
M3 - Article
C2 - 21813787
AN - SCOPUS:80055085252
SN - 0028-3878
VL - 77
SP - 818
EP - 826
JO - Neurology
JF - Neurology
IS - 9
ER -