TY - JOUR
T1 - Longitudinal changes in resting-state cerebral activity in patients with first-episode schizophrenia
T2 - A 1-year follow-up functional MR imaging study
AU - Li, Fei
AU - Lui, Su
AU - Yao, Li
AU - Hu, Junmei
AU - Lv, Peilin
AU - Huang, Xiaoqi
AU - Mechelli, Andrea
AU - Sweeney, John A.
AU - Gong, Qiyong
N1 - Funding Information:
1From the Huaxi MR Research Center, Department of Radiology (F.L., S.L., L.Y., X.H., Q.G.), Department of Psychiatry, Stat Key Laboratory of Biotherapy (J.H., Q.G.), and Department of Anaesthesiology (P.L.), West China Hospital of Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China; School of Basic Science and Forensic Medicine (J.H.) and Department of Psychology, School of Public Administration (Q.G.), Sichuan University, Sichuan, China; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, England (A.M.); and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Tex (J.A.S.). Received June 16, 2015; revision requested August 10; revision received October 2; accepted October 2; final version accepted October 16. Supported by the National Natural Science Foundation (grants 81220108013, 81222018,, 81371527, 81227002), CMB Distinguished Professorship Award (F510000/G16916411), Changjiang Scholar Professorship Award (award no. T2014190, and Program for Changjiang Scholars and Innovative Research Team in University (grant IRT1272) of China. J.A.S. supported by a grant from the Humboldt Foundation. Address correspondence to Q.G. (e-mail: qiyonggong@hmrrc.org.cn).
Funding Information:
closed no relevant relationships. S.L. disclosed no relevant relationships. L.Y. disclosed no relevant relationships. J.H. disclosed no relevant relationships. P.L. disclosed no relevant relationships. X.H. disclosed no relevant relationships. A.M. disclosed no relevant relationships. J.A.S. Financial activities related to the present article: disclosed no relevant relationships. Financial activities not related to the present article: personal fees from Eli Lilly and Takeda and a grant from Janssen. Other relationships: disclosed no relevant relationships. Q.G. disclosed no relevant relationships.
Publisher Copyright:
© 2016 RSNA.
PY - 2016/6
Y1 - 2016/6
N2 - Purpose: To determine whether the brain functional abnormalities of drug-naive first-episode schizophrenia are reduced after 1 year of undergoing antipsychotic treatment and whether pretreatment resting-state functional magnetic resonance (MR) imaging parameters are associated with longitudinal changes in clinical symptoms. Materials and Methods: This prospective study was approved by the local ethical committee, and written informed consent was obtained from all participants. Twenty antipsychotic-naive first-episode patients with schizophrenia and 16 healthy individuals were recruited and underwent resting-state functional MR imaging at baseline and again at 1-year follow-up, by which time significant clinical improvement was seen. The amplitude of low-frequency fluctuation (ALFF) and seedbased functional connectivity (FC) were analyzed with analysis of covariance. Results: The amount of ALFF in the right inferior parietal lobule (IPL) and orbitofrontal cortex (OFC) and the amount of FC between the bilateral IPLs significantly increased over the follow-up period, and the amount of ALFF in the right occipital gyrus was reduced (P < .050, AlphaSim corrected [http://afni.nimh.nih.gov/pub/dist/doc/manual/Alpha-Sim.pdf]), returning toward normal levels. Furthermore, the degree of alteration in ALFF values in the right OFC (P = .037) and occipital gyrus (P = .002) at baseline was significantly correlated with the magnitude of the normalization in those regions at 1-year follow-up. In contrast, abnormalities of ALFF in the bilateral thalamus, ventral medial prefrontal cortex, precuneus, and right amygdala and of FC between the right OFC and the dorsal medial prefrontal cortex at baseline did not improve in patients at 1-year follow-up. Conclusion: These findings show that some, but not all, neurophysiologic alterations that occur during the acute phase of schizophrenia are normalized in the context of clinical improvement and suggest therapeutic implications for exploration of which alterations in regional and network-level brain function evolve over time in patients with schizophrenia and which reflect persistent pathologic traits.
AB - Purpose: To determine whether the brain functional abnormalities of drug-naive first-episode schizophrenia are reduced after 1 year of undergoing antipsychotic treatment and whether pretreatment resting-state functional magnetic resonance (MR) imaging parameters are associated with longitudinal changes in clinical symptoms. Materials and Methods: This prospective study was approved by the local ethical committee, and written informed consent was obtained from all participants. Twenty antipsychotic-naive first-episode patients with schizophrenia and 16 healthy individuals were recruited and underwent resting-state functional MR imaging at baseline and again at 1-year follow-up, by which time significant clinical improvement was seen. The amplitude of low-frequency fluctuation (ALFF) and seedbased functional connectivity (FC) were analyzed with analysis of covariance. Results: The amount of ALFF in the right inferior parietal lobule (IPL) and orbitofrontal cortex (OFC) and the amount of FC between the bilateral IPLs significantly increased over the follow-up period, and the amount of ALFF in the right occipital gyrus was reduced (P < .050, AlphaSim corrected [http://afni.nimh.nih.gov/pub/dist/doc/manual/Alpha-Sim.pdf]), returning toward normal levels. Furthermore, the degree of alteration in ALFF values in the right OFC (P = .037) and occipital gyrus (P = .002) at baseline was significantly correlated with the magnitude of the normalization in those regions at 1-year follow-up. In contrast, abnormalities of ALFF in the bilateral thalamus, ventral medial prefrontal cortex, precuneus, and right amygdala and of FC between the right OFC and the dorsal medial prefrontal cortex at baseline did not improve in patients at 1-year follow-up. Conclusion: These findings show that some, but not all, neurophysiologic alterations that occur during the acute phase of schizophrenia are normalized in the context of clinical improvement and suggest therapeutic implications for exploration of which alterations in regional and network-level brain function evolve over time in patients with schizophrenia and which reflect persistent pathologic traits.
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U2 - 10.1148/radiol.2015151334
DO - 10.1148/radiol.2015151334
M3 - Article
C2 - 27007945
AN - SCOPUS:85008641934
SN - 0033-8419
VL - 279
SP - 867
EP - 875
JO - RADIOLOGY
JF - RADIOLOGY
IS - 3
ER -