Abstract
1. Long-term potentiation (LTP) of excitatory postsynaptic potentials (epsp's) was investigated with extracellular field potential recording in hippocampal slices from rats. 2. In the presence of 100 μM 4-aminopyridine (4-AP) the probability of eliciting LTP was unchanged or increased; the extent of potentiation was not significantly different from normal. 3. During LTP saturation, 4-AP further enhanced the epsp. 4. These data are inconsistent with an involvement of A-current reduction in LTP.
Original language | English (US) |
---|---|
Pages (from-to) | 297-301 |
Number of pages | 5 |
Journal | Cellular and Molecular Neurobiology |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1985 |
Keywords
- 4-aminopyridine
- hippocampal slice
- long-term potentiation
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology