Long-term changes in quality of life after endoscopic resection of sinonasal and skull-base tumors

Taylor Derousseau, Lakshman Manjunath, Brian Harrow, Song Zhang, Pete S. Batra

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: Minimally invasive endoscopic resection (MIER) has emerged as the new standard for surgical treatment of sinonasal and skull-base tumors. The objective of the present study was to evaluate quality of life (QOL) 2 years after MIER. Methods: Prospective 20-item Sino-Nasal Outcome Test (SNOT-20) data was accrued on 104 patients over 4 years. The study cohort included 72 patients with sinonasal malignancy, while 32 patients with inverted papilloma (IP) served as controls. Results: The overall and rhinologic subdomain SNOT-20 scores for cancer patients did not statistically improve at 2 years (p = 0.12). They had statistically significant improvement in the psychological subdomain scores at 1 year (p = 0.03) and 2 years (p = 0.03). Similarly, the sleep subdomain scores improved at 1 year (p = 0.04) and 2 years (p = 0.03). In contrast, IP patients had statistically significant improvement in overall SNOT-20 (p = 0.01), rhinologic (p = 0.01), and sleep (p = 0.05) subdomain scores at 6 months, which remained stable at 2 years. Analysis of various factors demonstrated that history of prior smoking adversely affected QOL scores in cancer patients, with higher total SNOT-20 scores than nonsmokers (p = 0.01). Smokers also had higher psychological (p = 0.04), sleep (p = 0.01), and ear/facial (p = 0.001) domain scores than nonsmokers at 2 years. Conclusion: The long-term effects of MIER for sinus cancer showed improved psychological and sleep scores at both 1 year and 2 years. Unfortunately, rhinologic QOL did not statistically improve at any of the measured time points. History of smoking was noted to be the most important predictor of QOL 2 years after MIER for sinonasal malignancy.

Original languageEnglish (US)
Pages (from-to)1129-1135
Number of pages7
JournalInternational Forum of Allergy and Rhinology
Issue number12
StatePublished - Dec 1 2015


  • MIER
  • Neoplasm
  • Quality of life
  • Sinonasal
  • Sinus
  • Skull base
  • Tumor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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