TY - JOUR
T1 - Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure
AU - Goldsmith, Rochelle L.
AU - Bigger, J. Thomas
AU - Bloomfield, Daniel M.
AU - Krum, Henry
AU - Steinman, Richard C.
AU - Sackner-Bernstein, Jonathan
AU - Packer, Milton
PY - 1997/10/15
Y1 - 1997/10/15
N2 - To determine the effect of β blockade on parasympathetic nervous system activity, we assessed RR variability during 24-hour Holter monitoring in 10 patients with congestive heart failure before and after 3 to 4 months of treatment with the β blocker carvedilol. High-frequency power increased from 26 to 64 ms2, root-mean-square of successive differences in RR interval increased from 14.3 to 23.7 ms2, and percentage of absolute differences >50 ms between successive normal RR intervals increased from 0.8% to 4.7%, all p < 0.01, indicating a substantial increase in parasympathetic modulation of RR intervals.
AB - To determine the effect of β blockade on parasympathetic nervous system activity, we assessed RR variability during 24-hour Holter monitoring in 10 patients with congestive heart failure before and after 3 to 4 months of treatment with the β blocker carvedilol. High-frequency power increased from 26 to 64 ms2, root-mean-square of successive differences in RR interval increased from 14.3 to 23.7 ms2, and percentage of absolute differences >50 ms between successive normal RR intervals increased from 0.8% to 4.7%, all p < 0.01, indicating a substantial increase in parasympathetic modulation of RR intervals.
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U2 - 10.1016/S0002-9149(97)00616-4
DO - 10.1016/S0002-9149(97)00616-4
M3 - Article
C2 - 9352991
AN - SCOPUS:0030726481
SN - 0002-9149
VL - 80
SP - 1101
EP - 1104
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 8
ER -