Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA

Dwaine A. Braasch, David R. Corey

Research output: Contribution to journalShort surveypeer-review

517 Scopus citations


Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2′-oxygen and the 4′-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalChemistry and Biology
Issue number1
StatePublished - 2001


  • DNA recognition
  • Gene expression control
  • Locked nucleic acid
  • RNA recognition

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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