Lock and key to transcription: σ-DNA interaction

Xin Liu; David A. Bushnell; Roger D. Kornberg

doi:10.1016/j.cell.2011.11.033

Lock and key to transcription: σ-DNA interaction

Xin Liu, David A. Bushnell, Roger D. Kornberg

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these two processes are interconnected.

Original language	English (US)
Pages (from-to)	1218-1219
Number of pages	2
Journal	Cell
Volume	147
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2011.11.033
State	Published - Dec 9 2011

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2011.11.033

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title = "Lock and key to transcription: σ-DNA interaction",

abstract = "How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these two processes are interconnected.",

author = "Xin Liu and Bushnell, {David A.} and Kornberg, {Roger D.}",

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AU - Liu, Xin

AU - Bushnell, David A.

AU - Kornberg, Roger D.

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N2 - How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these two processes are interconnected.

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Lock and key to transcription: σ-DNA interaction

Abstract

ASJC Scopus subject areas

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