Localization of acetylated histone H4 in the macronucleus of Euplotes

Donald E. Olins, Ada L. Olins, Adria Herrmann, Rueyling Lin, C. David Allis, Michel Robert-Nicoud

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Antisera specific to acetylated and unacetylated N-terminal domains of histone H4 were employed to map the spatial distribution of exposed antigenic determinants in the macronucleus of Euplotes eurystomus. Sites of putative transcription-related acetylation appear to reside in the regions between condensed chromatin granules and disappear during chromatin restructuring in the forward zone of replication bands. Coincident with synthesis of newly replicated chromatin, the specific antisera reveal a resumption of exposed sites of H4 acetylation in the rear zone of replication bands.

Original languageEnglish (US)
Pages (from-to)377-385
Number of pages9
Issue number6
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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