@article{f32d248379604cf59a06eff3f9858758,
title = "Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity",
abstract = "Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.",
author = "Mashito Sakai and Troutman, {Ty D.} and Seidman, {Jason S.} and Zhengyu Ouyang and Spann, {Nathanael J.} and Yohei Abe and Ego, {Kaori M.} and Bruni, {Cassi M.} and Zihou Deng and Schlachetzki, {Johannes C.M.} and Alexi Nott and Hunter Bennett and Jonathan Chang and Vu, {Bao Chau T.} and Pasillas, {Martina P.} and Link, {Verena M.} and Lorane Texari and Sven Heinz and Thompson, {Bonne M.} and McDonald, {Jeffrey G.} and Frederic Geissmann and Glass, {Christopher K.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
day = "15",
doi = "10.1016/j.immuni.2019.09.002",
language = "English (US)",
volume = "51",
pages = "655--670.e8",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",
}