Liver and pancreas: Mechanisms of development and size control

Ravi Maddipati, Ben Z. Stanger

Research output: Chapter in Book/Report/Conference proceedingChapter


The Gastrointestinal (GI) system is primarily comprised of the liver, pancreas and luminal tract. Together, these organs play a critical role in nutrient homeostasis, synthetic function and toxin removal (Table 1). The liver is mainly responsible for sustaining serum protein and metabolite concentrations, drug metabolism, detoxification and bile production. The endocrine pancreas works to tightly control serum glucose metabolism while it’s exocrine portion aides in digestion of nutrients. The GI tract functions to digest food, extract nutrients and dispose of waste. Despite their varied functions, these organs share a common embryological origin, being derived primarily from the endoderm with contributions from mesoderm and ectoderm germ layers (Table 2). Advances over the past 1-2 decades have given us insight into the genes, transcription factors and pathways involved in the patterning, morphogenesis and differentiation of gut endoderm.

Original languageEnglish (US)
Title of host publicationStem Cells
Subtitle of host publicationFrom Basic Research to Therapy, Volume 1: Basic Stem Cell Biology, Tissue Formation during Development, and Model Organisms
PublisherCRC Press
Number of pages43
ISBN (Electronic)9781482207767
ISBN (Print)9781482207750
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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