Lipoprotein receptors: New roles for ancient proteins

Thomas E. Willnow, Anders Nykjaer, Joachim Herz

Research output: Contribution to journalReview articlepeer-review

187 Scopus citations


Lipoprotein receptors used to be viewed simply as the means by which cells were supplied with lipids for energy production and membrane synthesis. This perception has now changed dramatically. Megalin, a member of the low density lipoprotein receptor gene family, turns out to mediate the endocytic uptake of retinoids and steroids, thus helping to regulate their biological function. Other members of this receptor family interact with cytosolic signalling proteins, giving this evolutionarily ancient family of receptors an entirely unexpected new role as transducers of extracellular signals.

Original languageEnglish (US)
Pages (from-to)E157-E162
JournalNature cell biology
Issue number6
StatePublished - Oct 1999

ASJC Scopus subject areas

  • Cell Biology


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