Lipids in innate antiviral defense

John W. Schoggins; Glenn Randall

doi:10.1016/j.chom.2013.09.010

Lipids in innate antiviral defense

John W. Schoggins, Glenn Randall

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

It is becoming apparent that infections by a major class of viruses, those with envelopes, can be inhibited during their entry at the step of fusion with cellular membranes. In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid composition of cellular and viral membranes to inhibit virion fusion of enveloped viruses.

Original language	English (US)
Pages (from-to)	379-385
Number of pages	7
Journal	Cell Host and Microbe
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2013.09.010
State	Published - Oct 16 2013

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2013.09.010

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title = "Lipids in innate antiviral defense",

abstract = "It is becoming apparent that infections by a major class of viruses, those with envelopes, can be inhibited during their entry at the step of fusion with cellular membranes. In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid composition of cellular and viral membranes to inhibit virion fusion of enveloped viruses.",

author = "Schoggins, {John W.} and Glenn Randall",

note = "Funding Information: We thank David Russell and Vineela Chukkapalli for helpful discussions. Unfortunately, due to space limitations, we were unable to cite all relevant literature and apologize to those omitted. G.R. is supported by NIAID (AI080703 and AI102236), the American Cancer Society (118676-RSG-10-059-01-MPC), and Susan and David Sherman. J.W.S. is supported by NIDDK (DK095031).",

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AU - Schoggins, John W.

AU - Randall, Glenn

N1 - Funding Information: We thank David Russell and Vineela Chukkapalli for helpful discussions. Unfortunately, due to space limitations, we were unable to cite all relevant literature and apologize to those omitted. G.R. is supported by NIAID (AI080703 and AI102236), the American Cancer Society (118676-RSG-10-059-01-MPC), and Susan and David Sherman. J.W.S. is supported by NIDDK (DK095031).

PY - 2013/10/16

Y1 - 2013/10/16

N2 - It is becoming apparent that infections by a major class of viruses, those with envelopes, can be inhibited during their entry at the step of fusion with cellular membranes. In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid composition of cellular and viral membranes to inhibit virion fusion of enveloped viruses.

AB - It is becoming apparent that infections by a major class of viruses, those with envelopes, can be inhibited during their entry at the step of fusion with cellular membranes. In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid composition of cellular and viral membranes to inhibit virion fusion of enveloped viruses.

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U2 - 10.1016/j.chom.2013.09.010

DO - 10.1016/j.chom.2013.09.010

M3 - Review article

C2 - 24139397

AN - SCOPUS:84886071901

SN - 1931-3128

VL - 14

SP - 379

EP - 385

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

Lipids in innate antiviral defense

Abstract

ASJC Scopus subject areas

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