TY - JOUR
T1 - Lipid transfer and signaling at organelle contact sites
T2 - The tip of the iceberg
AU - Toulmay, Alexandre
AU - Prinz, William A.
N1 - Funding Information:
This work was supported by the Intramural Research Fund of the National Institute of Diabetes and Digestive and Kidney Diseases .
PY - 2011/8
Y1 - 2011/8
N2 - Membrane contact sites (MCSs) are formed by the close apposition of membranes of two organelles. They are zones where signals and small molecules, such as lipids and calcium, are exchanged between intracellular compartments. The past few years have seen considerable progress in our understanding of how MCSs form and facilitate the exchange of lipids and signals. Here we summarize what has been learned about MCSs between the endoplamic reticulum (ER) and the plasma membrane, the ER and mitochondria, and the ER and endosomes or lysosomes. These findings suggest that we are just beginning to understand how MCSs form and function.
AB - Membrane contact sites (MCSs) are formed by the close apposition of membranes of two organelles. They are zones where signals and small molecules, such as lipids and calcium, are exchanged between intracellular compartments. The past few years have seen considerable progress in our understanding of how MCSs form and facilitate the exchange of lipids and signals. Here we summarize what has been learned about MCSs between the endoplamic reticulum (ER) and the plasma membrane, the ER and mitochondria, and the ER and endosomes or lysosomes. These findings suggest that we are just beginning to understand how MCSs form and function.
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U2 - 10.1016/j.ceb.2011.04.006
DO - 10.1016/j.ceb.2011.04.006
M3 - Review article
C2 - 21555211
AN - SCOPUS:79960739849
SN - 0955-0674
VL - 23
SP - 458
EP - 463
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 4
ER -