TY - JOUR
T1 - Lipid trafficking sans vesicles
T2 - Where, why, how?
AU - Prinz, William A.
N1 - Funding Information:
I thank Ted Steck, Jim Hurley, and Tim Schulz for reading the manuscript. This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases.
PY - 2010/12/10
Y1 - 2010/12/10
N2 - Eukaryotic cells possess a remarkable diversity of lipids, which distribute among cellular membranes by well-characterized vesicle trafficking pathways. However, transport of lipids by alternate, or "nonvesicular," routes is also critical for lipid synthesis, metabolism, and proper membrane partitioning. In the past few years, considerable progress has been made in characterizing the mechanisms of nonvesicular lipid transport and how it may go awry in particular diseases, but many fundamental questions remain for this rising field.
AB - Eukaryotic cells possess a remarkable diversity of lipids, which distribute among cellular membranes by well-characterized vesicle trafficking pathways. However, transport of lipids by alternate, or "nonvesicular," routes is also critical for lipid synthesis, metabolism, and proper membrane partitioning. In the past few years, considerable progress has been made in characterizing the mechanisms of nonvesicular lipid transport and how it may go awry in particular diseases, but many fundamental questions remain for this rising field.
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U2 - 10.1016/j.cell.2010.11.031
DO - 10.1016/j.cell.2010.11.031
M3 - Short survey
C2 - 21145454
AN - SCOPUS:78649967779
SN - 0092-8674
VL - 143
SP - 870
EP - 874
JO - Cell
JF - Cell
IS - 6
ER -