Abstract
Background: Lipid bilayer composition and asymmetry modulate K+ channel function by unknown mechanisms. Results: Lipid headgroups with exposed hydroxyls on the extracellular facing monolayer stabilize the channel open conformation irrespective of charge. Conclusion: Stabilization is mediated through a change of interfacial water structure. Significance: Lipid bilayer asymmetry and its individual monolayers emerge as crucial determinants of K channel gating.
Original language | English (US) |
---|---|
Pages (from-to) | 4233-4243 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 7 |
DOIs | |
State | Published - Feb 14 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology