Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Peng Xiao; Wei Yan; Lu Gou; Ya Ni Zhong; Liangliang Kong; Chao Wu; Xin Wen; Yuan Yuan; Sheng Cao; Changxiu Qu; Xin Yang; Chuan Cheng Yang; Anjie Xia; Zhenquan Hu; Qianqian Zhang; Yong Hao He; Dao Lai Zhang; Chao Zhang; Gui Hua Hou; Huanxiang Liu; Lizhe Zhu; Ping Fu; Shengyong Yang; Daniel M. Rosenbaum; Jin Peng Sun; Yang Du; Lei Zhang; Xiao Yu; Zhenhua Shao

doi:10.1016/j.cell.2021.01.028

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Peng Xiao, Wei Yan, Lu Gou, Ya Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong Hao He, Dao Lai Zhang, Chao Zhang, Gui Hua Hou, Huanxiang LiuLizhe Zhu, Ping Fu, Shengyong Yang, Daniel M. Rosenbaum, Jin Peng Sun, Yang Du, Lei Zhang, Xiao Yu, Zhenhua Shao

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.

Original language	English (US)
Pages (from-to)	943-956.e18
Journal	Cell
Volume	184
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2021.01.028
State	Published - Feb 18 2021

Keywords

DRD1-Gs complex
allosteric regulation
catecholamine
ccryo-EM
dopamine receptor
noncatechol
positive allosteric modulator
structure

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2021.01.028

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Xiao, P, Yan, W, Gou, L, Zhong, YN, Kong, L, Wu, C, Wen, X, Yuan, Y, Cao, S, Qu, C, Yang, X, Yang, CC, Xia, A, Hu, Z, Zhang, Q, He, YH, Zhang, DL, Zhang, C, Hou, GH, Liu, H, Zhu, L, Fu, P, Yang, S, Rosenbaum, DM, Sun, JP, Du, Y, Zhang, L, Yu, X & Shao, Z 2021, 'Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes', Cell, vol. 184, no. 4, pp. 943-956.e18. https://doi.org/10.1016/j.cell.2021.01.028

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title = "Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes",

abstract = "The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.",

keywords = "DRD1-Gs complex, allosteric regulation, catecholamine, ccryo-EM, dopamine receptor, noncatechol, positive allosteric modulator, structure",

author = "Peng Xiao and Wei Yan and Lu Gou and Zhong, {Ya Ni} and Liangliang Kong and Chao Wu and Xin Wen and Yuan Yuan and Sheng Cao and Changxiu Qu and Xin Yang and Yang, {Chuan Cheng} and Anjie Xia and Zhenquan Hu and Qianqian Zhang and He, {Yong Hao} and Zhang, {Dao Lai} and Chao Zhang and Hou, {Gui Hua} and Huanxiang Liu and Lizhe Zhu and Ping Fu and Shengyong Yang and Rosenbaum, {Daniel M.} and Sun, {Jin Peng} and Yang Du and Lei Zhang and Xiao Yu and Zhenhua Shao",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = feb,

day = "18",

doi = "10.1016/j.cell.2021.01.028",

language = "English (US)",

volume = "184",

pages = "943--956.e18",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "4",

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TY - JOUR

T1 - Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

AU - Xiao, Peng

AU - Yan, Wei

AU - Gou, Lu

AU - Zhong, Ya Ni

AU - Kong, Liangliang

AU - Wu, Chao

AU - Wen, Xin

AU - Yuan, Yuan

AU - Cao, Sheng

AU - Qu, Changxiu

AU - Yang, Xin

AU - Yang, Chuan Cheng

AU - Xia, Anjie

AU - Hu, Zhenquan

AU - Zhang, Qianqian

AU - He, Yong Hao

AU - Zhang, Dao Lai

AU - Zhang, Chao

AU - Hou, Gui Hua

AU - Liu, Huanxiang

AU - Zhu, Lizhe

AU - Fu, Ping

AU - Yang, Shengyong

AU - Rosenbaum, Daniel M.

AU - Sun, Jin Peng

AU - Du, Yang

AU - Zhang, Lei

AU - Yu, Xiao

AU - Shao, Zhenhua

PY - 2021/2/18

Y1 - 2021/2/18

N2 - The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.

AB - The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.

KW - DRD1-Gs complex

KW - allosteric regulation

KW - catecholamine

KW - ccryo-EM

KW - dopamine receptor

KW - noncatechol

KW - positive allosteric modulator

KW - structure

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U2 - 10.1016/j.cell.2021.01.028

DO - 10.1016/j.cell.2021.01.028

M3 - Article

C2 - 33571432

AN - SCOPUS:85100630126

SN - 0092-8674

VL - 184

SP - 943-956.e18

JO - Cell

JF - Cell

IS - 4

ER -

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Abstract

Keywords

ASJC Scopus subject areas

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