Life after per-oral endoscopic myotomy: long-term outcomes of quality of life and their association with Eckardt scores

Yaseen B. Perbtani, Lazarus K. Mramba, Dennis Yang, Jorge Suarez, Peter V. Draganov

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background and Aims: The clinical efficacy of per-oral endoscopic myotomy (POEM) has been commonly established by reduction in the Eckardt score (<3) after the procedure. However, achalasia can lead to significant impairment in the patient's quality of life that may go beyond the 4 classic achalasia symptoms as measured by the Eckardt score. The aims of our study were to evaluate the effect of POEM on short-term and long-term health-related quality of life (HRQOL) and to assess the association between HRQOL and Eckardt scores. Methods: Single-center, prospective, cohort study of consecutive POEMs during a 3-year period. Eckardt and HRQOL scores as measured by the short-form survey questionnaire (SF-36) were obtained at baseline and at various intervals after POEM. Comparison of the mean scores was described by using univariate linear regression. The association between Eckardt scores and HRQOL were calculated by using a linear, mixed-model analysis. Results: POEM was performed in 143 consecutive patients (54% male; mean ± standard deviation [SD] age, 56.9 ± 17.9 years). At long-term follow-up (mean 16.4 months, range 12-40), both the HRQOL baseline mental and physical component scores improved significantly from 61.5 ± 2.2 to 71.2 ± 3.6; (P <.021) and from 55.8 ± 2.2 to 63.6 ± 3.3; (P = <.034), respectively. Mixed-model analysis showed a significant association between Eckardt and all HRQOL scores (P <.001). Conclusion: POEM improved all dimensions of HRQOL as measured by the SF-36 survey at both short-term and long-term follow-up. A strong association was seen between Eckardt scores and all HRQOL domains. Further studies with the use of disease-specific HRQOL instruments are warranted. (Clinical trial registration number: NCT01832779.)

Original languageEnglish (US)
Pages (from-to)1415-1420.e1
JournalGastrointestinal endoscopy
Issue number6
StatePublished - Jun 2018
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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