Letermovir successfully used for secondary prophylaxis in a heart transplant recipient with ganciclovir-resistant cytomegalovirus syndrome (UL97 mutation)

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33 Scopus citations

Abstract

Letermovir was approved by the Food and Drug Administration (FDA) in November 2017 for use in adult cytomegalovirus (CMV)-seropositive allogeneic stem cell transplant (SCT) recipients for primary prophylaxis of CMV infection and disease. We report off-label use of letermovir for secondary prophylaxis of genotype-confirmed ganciclovir-resistant cytomegalovirus (CMV) syndrome (UL 97 mutation [C603W]) in a heart transplant recipient initially treated with intravenous cidofovir followed by foscarnet, both discontinued due to unacceptable toxicities.

Original languageEnglish (US)
Article numbere12965
JournalTransplant Infectious Disease
Volume20
Issue number5
DOIs
StatePublished - Oct 2018

Keywords

  • UL97 mutation
  • cytomegalovirus
  • ganciclovir resistance
  • heart transplant
  • letermovir

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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