Lessons from human genetic variants in the study of B-cell differentiation

Anne B. Satterthwaite, Owen N. Witte

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Several human B-cell immunodeficiencies result from mutations in signal transducing molecules. The past year has seen significant advances in our understanding of how these molecules are integrated into B cell signaling pathways. The phenotypes of mice deficient in several of these genes have revealed species-specific differences in the requirements for early B cell development.

Original languageEnglish (US)
Pages (from-to)454-458
Number of pages5
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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