Leptin beyond the lipostat: Key component of blood pressure regulation

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Obese individuals often struggle with increases in blood pressure (BP) that ultimately lead to an enhanced cardiovascular disease (CVD) risk. The mechanistic basis for this association has remained largely unknown. Although a large number of metabolic signals are altered in obese individuals, including dyslipidemia, associated changes in sphingolipids, and an overall increase in subclinical inflammation, none of these parameters are thought to greatly influence BP. Recent data suggest that the adipokine leptin, whose circulating levels are typically proportional to fat mass, is a major driving force for the obesity-associated increases in BP. The effects of leptin on BP are mediated by neuronal circuits, including leptin-responsive neurons in the dorsomedial hypothalamic (DMH) nucleus.

Original languageEnglish (US)
Pages (from-to)1293-1295
Number of pages3
JournalCirculation research
Issue number8
StatePublished - Apr 10 2015


  • Adipokines
  • Blood pressure
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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