TY - JOUR
T1 - Lenticulostriate vasculopathy in preterm infants
T2 - a new classification, clinical associations and neurodevelopmental outcome
AU - Sisman, Julide
AU - Chalak, Lina
AU - Heyne, Roy
AU - Pritchard, Marcia
AU - Weakley, Devri
AU - Brown, L. Steven
AU - Rosenfeld, Charles R.
N1 - Publisher Copyright:
© 2018, Springer Nature America, Inc.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Objective: To examine the inter-rater reliability for the diagnosis of LSV on cranial ultrasound (cUS), determine the risk factors associated with LSV and its progression, and examine neurodevelopmental outcome. Study design: Prospective case–control study of neonates ≤32wks of gestation assessed for LSV by serial cUS (n = 1351) between 2012 and 2014 and their neurodevelopment at 18–36mon-corrected age compared to controls. Results: Agreement for LSV on cUS improved from Κappa 0.4–0.7 after establishing definitive criteria and guidelines. BPD was the only variable associated with the occurrence and the progression of LSV. Cytomegalovirus (CMV) infection occurred in one neonate (1.5%). Neurodevelopmental outcome of neonates with LSV did not differ from controls. Conclusions: Establishment of well-defined stages of LSV improves the reliability of the diagnosis and allows identification of neonates with progression of LSV. Although LSV was associated with BPD, it was not associated with congenital CMV infection.
AB - Objective: To examine the inter-rater reliability for the diagnosis of LSV on cranial ultrasound (cUS), determine the risk factors associated with LSV and its progression, and examine neurodevelopmental outcome. Study design: Prospective case–control study of neonates ≤32wks of gestation assessed for LSV by serial cUS (n = 1351) between 2012 and 2014 and their neurodevelopment at 18–36mon-corrected age compared to controls. Results: Agreement for LSV on cUS improved from Κappa 0.4–0.7 after establishing definitive criteria and guidelines. BPD was the only variable associated with the occurrence and the progression of LSV. Cytomegalovirus (CMV) infection occurred in one neonate (1.5%). Neurodevelopmental outcome of neonates with LSV did not differ from controls. Conclusions: Establishment of well-defined stages of LSV improves the reliability of the diagnosis and allows identification of neonates with progression of LSV. Although LSV was associated with BPD, it was not associated with congenital CMV infection.
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U2 - 10.1038/s41372-018-0206-8
DO - 10.1038/s41372-018-0206-8
M3 - Article
C2 - 30115968
AN - SCOPUS:85052497484
SN - 0743-8346
VL - 38
SP - 1370
EP - 1378
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 10
ER -