Left ventricular function in mitral stenosis

L. D. Horwitz, C. B. Mullins, R. M. Payne, G. C. Curry

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


The effects of isometric exercise on left ventricular performance were studied during cardiac catheterization in six patients with mitral stenosis and six patients without significant cardiac disease. Quantitative analyses of left ventricular cineangiograms were completed to correlate changes with the findings during exercise. During exercise, left ventricular function curves were abnormal in five of the six patients with mitral stenosis. In addition, ejection fractions were significantly lower in the group with mitral stenosis as compared with the normal subjects. The lower ejection fractions in the patient with mitral stenosis were due to localized abnormalities in the posterobasal and anterior left ventricular walls. It is concluded that left ventricular function is abnormal in mitral stenosis due to localized wall motion abnormalities, which are probably due to fibrosis near or in the papillary muscles.

Original languageEnglish (US)
Pages (from-to)609-614
Number of pages6
Issue number5
StatePublished - 1973

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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